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Gas exchange and respiration

           The  hydrogen atoms  carried by reduced  a total of 2 ATP molecules as it passes
           NAD and FAD are transferred to a chain  through the carriers. Initially, hydrogen
           of  other  carriers  at  progressively  lower  atoms pass along the chain. However, after
           energy levels.  As the  hydrogen passes  the FAD stage, they split into protons (H )
                                                                                            +
           from  one  carrier  to  the  next,  the  energy  and electrons.  The former takes another
           released  is used to combine  ADP and  route out of the chain  as the  electrons
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           inorganic phosphate (Pi) to form ATP. A  pass through the cytochrome system.
           series of carriers is termed the respiratory  Accordingly,  the  pathway  can  be  called
           chain. The latter has four electron carriers,  the electron transport system. Oxygen is
           namely  NAD, FAD,  coenzyme  Q and         the final electron acceptor in the electron
           cytochromes. The hydrogen atoms carried    transport  system. Finally, protons and
           by NAD are  shunted  into  the  chain  at   electrons  recombine  to form hydrogen
           carrier one, NAD (a step ahead FAD), and   atoms which create  a link with oxygen
           produce a total of 3 ATP molecules as they   to form water, this reaction  is catalysed
           pass through the carriers  (Figure 6.13).
           Meanwhile, the hydrogen atoms carried      by the enzyme cytochrome oxidase. The
           by FAD are  introduced  in the  chain  at   formation of ATP through the oxidation
           carrier  two, FAD.  Therefore,  a pair of   of hydrogen atoms is called  oxidative
           hydrogen atoms carried by FAD  makes       phosphorylation (Figure 6.13).

                      4H +                    4H +               2H +        3H +
                                                                                        Space
                       I               CoQ     III      Cyt       IV
                                                         C                           Inner
                                                                             ATP
                      2e -                                                  synthase  Mitochondrial
                                    II                                               Membrane
                                   2e -
                                                      2H  +½ O  + 2e →H O               Matrix
                                                        +

                                                                 -
                                                             2
                                                                     2
              NADH       NAD +
                      2H +  FADH    FAD + 2H +
                                 2
                                                                      ADP + Pi    ATP + H O
                                                                                        2
                                      Figure 6.13: Electron transport chain   3H +
           Generally, in the electron transport chain  and uses 10 oxygen atoms (5 molecules
           each  reduced NAD molecule  results  in  of oxygen). Moreover, each reduced FAD
           the production of 3 ATP and the release of  molecule  (from  Kreb’s cycle) results in

           hydrogen, which combines  with oxygen  the production of 2  ATP, hence 2 FAD
           to form water. Therefore, the 10 reduced  molecules  produce 4  ATP. Overall, the
           NAD  molecules   (2 from glycolysis, 2  electron transport chain produces a total
           from conversion of pyruvate into Acetyl  of 34 ATP molecules from one molecule
           CoA and 6 from Kreb’s cycle) results in the  of glucose (Figure 6.14).
           production of 30 ATP, 10 water molecules


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